Microsatellite instability in Gastric Cancer: Between lights and shadows

Abstract Gastric cancer (GC) represents an important contributor to the global burden of cancer, being one most common and deadly malignancies worldwide. According TCGA ACRG classifications, microsatellite instable (MSI) group a significant subset GCs is currently in limelight many researches due its favorable survival outcome resectable stages compared stable tumors. MSI hypermutated phenotype triggers immunosurveillance, making this molecular subgroup promising candidate for immune checkpoint inhibitors treatment. Conversely, conflicting outcomes have been reported chemotherapy settings. Due clinical relevance these observations, review we report discuss molecular, pathological, prognostic, predictive features gastric